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dc.creatorMerino, Maria J.
dc.creatorNieman, Lynnette K.
dc.creatorZellmer, Ann W.
dc.creatorBremner, William J.
dc.creatorAxiotis, Constantine
dc.creatorBatista, Marcelo C.
dc.creatorCartledge, Tannia P.
dc.date2008-10-17T20:42:28Z
dc.date2008-10-17T20:42:28Z
dc.date1995-09
dc.date.accessioned2012-06-12T06:05:47Z
dc.date.available2012-06-12T06:05:47Z
dc.date.issued2012-06-12
dc.identifierFertil Steril. 1995 Sep;64(3):492-9
dc.identifierhttp://hdl.handle.net/1773/4420
dc.identifier.urihttps://repositorio.leon.uia.mx/xmlui/1773/4420
dc.descriptionOBJECTIVE: To investigate changes in menstrual cycle hormones and endometrial maturation that may contribute to the decline in fertility with aging. DESIGN: Prospective controlled clinical study. SETTING: Normal human volunteers in an academic research institution. SUBJECTS: Women with regular menstrual cycles. INTERVENTIONS: Thirty-two women, aged 20 to 30 or 40 to 50 years, had daily blood drawing starting on cycle day 6 to 10 and continuing until 2 days after the onset of next menses. In addition, 60 women, aged 20 to 30 or 40 to 50 years, had a total of 93 endometrial biopsies performed on day 7 to 9 after the LH surge. MAIN OUTCOME MEASURES: Serum LH, FSH, E2, inhibin, P, and placental protein 14 (PP14) levels and histologic maturation of the endometrium. RESULTS: Serum FSH levels were increased whereas inhibin concentrations were reduced in the luteal-follicular transition of women > 40 years. No other hormonal changes were seen in this population, including P and PP14 secretion. Disruption of endometrial maturation occurred at a similar frequency in both age groups. CONCLUSIONS: Follicular recruitment, but not luteal function or endometrial maturation, is disturbed in cycling women > 40 years and may contribute to the decline in fertility with aging.
dc.languageen_US
dc.publisherElsevier
dc.subjectfollicle-stimulating hormone
dc.subjectluteinizing hormone
dc.subjectplacental protein 14
dc.subjectestradiol
dc.subjectendometrial biopsy
dc.subjectprogesterone
dc.subjectinhibin
dc.subjectEstradiol, blood
dc.subjectResearch Support, Non-U.S. Gov't
dc.subjectEndometrium, physiology
dc.subjectFollicle Stimulating Hormone, blood
dc.subjectHormones, blood
dc.subjectFemale
dc.subjectMenstrual Cycle, physiology
dc.subjectHumans
dc.subjectInhibins, blood
dc.subjectPregnancy Proteins, blood
dc.subjectGlycoproteins
dc.subjectAdult
dc.subjectAging, physiology
dc.subjectLuteinizing Hormone, blood
dc.subjectProspective Studies
dc.subjectProgesterone, blood
dc.subjectMiddle Aged
dc.titleEffects of aging on menstrual cycle hormones and endometrial maturation
dc.typeArticle


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