Show simple item record

dc.creatorGroome, Nigel P.
dc.creatorBremner, William J.
dc.creatorMatsumoto, Alvin M.
dc.creatorMcNeilly, Alan S.
dc.creatorIllingworth, Peter J.
dc.creatorAnawalt, Bradley D.
dc.creatorBebb, Richard A.
dc.date2008-10-17T20:41:39Z
dc.date2008-10-17T20:41:39Z
dc.date1996-09
dc.date.accessioned2012-06-12T05:38:39Z
dc.date.available2012-06-12T05:38:39Z
dc.date.issued2012-06-12
dc.identifierJ Clin Endocrinol Metab. 1996 Sep;81(9):3341-5
dc.identifierhttp://hdl.handle.net/1773/4366
dc.identifier.urihttps://repositorio.leon.uia.mx/xmlui/1773/4366
dc.descriptionWe used a recently developed ELISA format to test the hypothesis that inhibin B is the physiologically active form of inhibin in men. We measured and compared inhibin A, inhibin B, and pro-alpha-C-related immunoreactive peptides (pro-alpha-C-RI) in normal men before and after perturbations of their gonadotropin levels and baseline values in normal men and men with various disturbances of the hypothalamic-pituitary-testicular axis including men with idiopathic hypogonadotropic hypogonadism, infertile men with elevated FSH, men with Klinefelter's syndrome, and orchidectomized men. Mean serum inhibin concentrations were significantly higher in normal men than untreated men with idiopathic hypogonadotropic hypogonadism, infertile men with elevated FSH, untreated men with Klinefelter's syndrome, and orchidectomized men (187 +/- 28 vs 45 +/- 11, 37 +/- 6, 11 +/- 3, and < or = 10 pg/mL, respectively; P < 0.05). Inhibin B levels were below the limit of detection in all of the orchidectomized men. Pro-alpha-C-RI levels were detectable in all men studied including the orchidectomized men, and no significant differences in the pro-alpha-C-RI levels were noted between the normal men and men with various testicular diseases were noted except that orchidectomized men had significantly lower pro-alpha-C-RI levels than all other groups (P < 0.05). Inhibin A was undetectable in all men tested in this study. Six normal men who were administered exogenous levonorgestrel and testosterone had significantly lower serum gonadotropin, inhibin B, and pro-alpha-C-RI levels during the treatment period than the control and recovery periods (P < 0.05). Ten normal men who were administered human recombinant FSH had significantly higher peak serum FSH (21.85 +/- 3.23 IU/L vs. 3.01 +/- 0.51 IU/L), inhibin B (311 +/- 88 pg/mL vs. 151 +/- 23 pg/mL) and pro-alpha-C-RI (646 +/- 69 vs. 402 +/- 38 pg/mL) levels during the treatment period than the baseline values (P < 0.05). We conclude that inhibin B is a unique testicular product that is not detectable in the sera of orchidectomized men, is responsive to FSH stimulation, and has a reciprocal relationship with serum FSH levels in men with various forms of testicular disease. Therefore, inhibin B is likely to be the physiologically important form of inhibin in men.
dc.languageen_US
dc.publisherEndocrine Society
dc.subjectandrology
dc.subjectmale contraception
dc.subjectklinefelter's syndrome
dc.subject5-alpha reductase inhibitors
dc.subjectspermatogenesis
dc.subjectcolchicine
dc.subjectreifenstein's syndrome
dc.subjectgonadotropins
dc.subjecttestosterone
dc.subjectFollicle Stimulating Hormone, blood
dc.subjectSertoli Cells, physiology
dc.subjectAdult
dc.subjectHypogonadism, blood
dc.subjectInhibins, blood
dc.subjectHumans
dc.subjectOrchiectomy
dc.subjectKlinefelter Syndrome, blood
dc.subjectMale
dc.subjectResearch Support, Non-U.S. Gov't
dc.subjectInfertility, Male, blood
dc.subjectMiddle Aged
dc.subjectResearch Support, U.S. Gov't, P.H.S.
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.
dc.subjectProtein Precursors, blood
dc.titleSerum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction
dc.typeArticle


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record