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dc.creatorSchwall, Ralph
dc.creatorSteiner, Robert A.
dc.creatorBremner, William J.
dc.creatorMason, Anthony J.
dc.creatorSchmelzer, Charles H.
dc.creatorMcLachlan, Robert I.
dc.creatorDahl, Kristine D.
dc.date2008-10-17T20:41:16Z
dc.date2008-10-17T20:41:16Z
dc.date1989-11
dc.date.accessioned2012-06-12T05:27:25Z
dc.date.available2012-06-12T05:27:25Z
dc.date.issued2012-06-12
dc.identifierEndocrinology. 1989 Nov;125(5):2787-9
dc.identifierhttp://hdl.handle.net/1773/4343
dc.identifier.urihttps://repositorio.leon.uia.mx/xmlui/1773/4343
dc.descriptionActivin-A is a homodimer of the beta A inhibin subunit that stimulates FSH secretion by pituitary cells in vitro; however, the physiological relevance of this effect is unknown. We have examined whether recombinant human activin-A (activin-A; 80 micrograms/kg/day iv infusion for 50.5 h) has in vivo bioactivity in the adult male macaque (n = 5). Serum FSH and LH bioactivity and serum testosterone (T) levels were measured on 2 control days and after 24 and 48 h of activin-A administration. Basal FSH levels increased significantly (p less than 0.05) by 17% at 24 h and 82% at 48 h during activin-A administration. No changes in basal LH or T levels were seen. The FSH and LH responses to GnRH (5 micrograms/kg, iv bolus) increased significantly (p less than 0.05) by 117% and 55% after 48 h of activin-A, respectively. A small (16%), but statistically significant (p less than 0.05), increase in the T response to the GnRH challenge was also noted. These data are preliminary evidence in support of a physiological role for activin-A in the control of gonadotropin secretion in the male primate.
dc.languageen_US
dc.publisherEndocrine Society
dc.subjectandrology
dc.subjectmale contraception
dc.subjectklinefelter's syndrome
dc.subject5-alpha reductase inhibitors
dc.subjectspermatogenesis
dc.subjectcolchicine
dc.subjectreifenstein's syndrome
dc.subjectgonadotropins
dc.subjecttestosterone
dc.subjectAnimals
dc.subjectReference Values
dc.subjectResearch Support, Non-U.S. Gov't
dc.subjectActivins
dc.subjectFemale
dc.subjectGonadorelin, pharmacology
dc.subjectBiological Assay
dc.subjectResearch Support, U.S. Gov't, P.H.S.
dc.subjectLuteinizing Hormone, blood, pharmacology, secretion
dc.subjectGranulosa Cells, drug effects
dc.subjectHumans
dc.subjectMale
dc.subjectFollicle Stimulating Hormone, blood, pharmacology, secretion
dc.subjectInhibins, pharmacology
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.
dc.subjectRecombinant Proteins, pharmacology
dc.subjectMice
dc.subjectMacaca fascicularis
dc.titleRecombinant human activin-A stimulates basal FSH and GnRH-stimulated FSH and LH release in the adult male macaque, Macaca fascicularis
dc.typeArticle


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