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dc.creatorCherrier, M. M.
dc.creatorBremner, William J.
dc.creatorHerbst, Karen L.
dc.creatorAmory, John K.
dc.creatorCraft, S.
dc.creatorMatsumoto, Alvin M.
dc.creatorAnawalt, Bradley D.
dc.date2008-10-17T20:40:49Z
dc.date2008-10-17T20:40:49Z
dc.date2002-07
dc.date.accessioned2012-06-12T05:17:22Z
dc.date.available2012-06-12T05:17:22Z
dc.date.issued2012-06-12
dc.identifierJ Clin Endocrinol Metab. 2002 Jul;87(7):3090-6
dc.identifierhttp://hdl.handle.net/1773/4323
dc.identifier.urihttps://repositorio.leon.uia.mx/xmlui/1773/4323
dc.descriptionWe examined the effects of sex steroids on cognitive functioning by exogenously manipulating circulating T levels in a group of healthy young men. Thirty-two men were randomized to receive 8 wk of treatment including: 1) im T enanthate 100 mg/wk plus daily oral placebo (T); 2) im placebo/wk plus 125 microg daily oral levonorgestrel (LNG); 3) im T enanthate 100 mg/wk plus 125 microg daily oral LNG (T + LNG); 4) im placebo/wk plus daily oral placebo. Cognitive functions were assessed at baseline and twice during treatment. Serum T and E2 levels were significantly increased in the T and T + LNG groups compared with baseline (P < 0.01) and T levels were significantly decreased in the LNG group (P < 0.05). Verbal memory significantly decreased in the LNG group (P < 0.01) and was maintained by coadministration of T in the T + LNG group. Divided attention was unaffected in the LNG group but improved significantly in the T + LNG group. In summary, decreased serum T levels induced by LNG or direct effects of the progestin, LNG, adversely affects verbal memory in normal young men. These results suggest that short-term changes in sex steroid levels have effects on cognitive function in healthy young men.
dc.languageen_US
dc.publisherEndocrine Society
dc.subjectandrology
dc.subjectmale contraception
dc.subjecttestosterone
dc.subjectcolchicine
dc.subject5-alpha reductase inhibitors
dc.subjectspermatogenesis
dc.subjectreifenstein's syndrome
dc.subjectklinefelter's syndrome
dc.subjectgonadotropins
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.
dc.subjectTime Factors
dc.subjectMale
dc.subjectResearch Support, U.S. Gov't, P.H.S.
dc.subjectAdult
dc.subjectHumans
dc.subjectResearch Support, Non-U.S. Gov't
dc.subjectMiddle Aged
dc.subjectTestosterone, administration & dosage, analogs & derivatives, blood, pharmacology
dc.subjectLevonorgestrel, administration & dosage, pharmacology
dc.subjectContraceptive Agents, Male, administration & dosage, pharmacology
dc.subjectAdministration, Oral
dc.subjectCognition, drug effects
dc.subjectPlacebos
dc.subjectNeuropsychological Tests
dc.subjectInjections, Intramuscular
dc.subjectEstradiol, blood
dc.titleCognitive effects of short-term manipulation of serum sex steroids in healthy young men
dc.typeArticle


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